UISS (UCLA Integrated Staging System, RCC)
UCLA Integrated Staging System (UISS; Zisman 2001/2002, Patard 2004 validation) for surgically resected, LOCALIZED (N0M0) renal cell carcinoma — integrates 1997 TNM stage, Fuhrman grade,…
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Primary tumor stage
- T4
- Fuhrman grade
- Grade 2
- ECOG performance status
- ECOG 0
Result: UISS tier: high risk
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Low
- T1, Fuhrman grade 1-2, ECOG 0 — ~92% 5-year overall survival.
- High
- T4 (any grade/ECOG), or T3 grade 2-4 with ECOG >= 1 — ~44% 5-year overall survival.
- Intermediate
- Every other localized (N0M0) combination — ~67% 5-year overall survival.
- Scope
- Localized (N0M0) only; node-positive / metastatic disease uses the metastatic-RCC models (IMDC, MSKCC).
What you enter
- Primary tumor stage (T, 1997 TNM)
- Fuhrman grade
- ECOG performance status (0 or >= 1)
How this is calculated
Zisman A, Pantuck AJ, Dorey F, et al. Improved prognostication of renal cell carcinoma using an integrated staging system. J Clin Oncol. 2001;19(6):1649-1657 (with Zisman 2002, 20(23):4559-4566; Patard 2004 validation). Localized N0M0 branch: low/intermediate/high. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.