SSIGN Score (RCC Cancer-Specific Survival)
SSIGN score — a 0-17 score for cancer-specific survival in clear-cell renal cell carcinoma, from primary tumor (pT) stage, regional nodes, distant metastasis, tumor size, Fuhrman nuclear grade, and coagulative tumor necrosis.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Primary tumor (pT) stage
- pT3 (+2)
- Fuhrman nuclear grade
- Grade 4 (+3)
- Coagulative tumor necrosis
- Present (+2)
Result: SSIGN 7 of 17 — high risk; ~57.7% (score 7-9) 5-year cancer-specific survival per source.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- 0-2
- Low risk; ~96.8% 5-year cancer-specific survival in the derivation.
- 3-5
- Intermediate risk; ~92.5% (3-4) to ~78.8% (5-6) 5-year cancer-specific survival.
- >= 6
- High risk; ~57.7% (7-9) down to ~18.1% (>= 10) 5-year cancer-specific survival. A survival estimate, not a treatment order.
What you enter
- Primary tumor (pT) stage
- Regional lymph nodes (pNx/pN0 or pN1/pN2)
- Distant metastasis (M0 or M1)
- Tumor size (< 5 cm or >= 5 cm)
- Fuhrman nuclear grade
- Coagulative tumor necrosis
How this is calculated
Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, Zincke H. An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score. J Urol. 2002;168(6):2395-2400. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.