MSKCC (Motzer) Metastatic RCC Risk
MSKCC (Motzer) risk group for metastatic renal-cell carcinoma from five prognostic factors — the pre-targeted-therapy model still used for stratification.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Karnofsky < 80%
- Yes
- LDH > 1.5× ULN
- Yes
Result: MSKCC: 2 factors — intermediate risk (median OS 10 mo).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Groups
- Favorable 0, intermediate 1–2, poor ≥ 3; the historical comparator to the modern IMDC model.
What you enter
- Karnofsky < 80%
- LDH > 1.5× ULN
- Hemoglobin < LLN
- Corrected calcium > 10 mg/dL
- Diagnosis to treatment < 1 year
How this is calculated
- Factors
- Karnofsky < 80%, LDH > 1.5× ULN, low hemoglobin, high corrected calcium, dx-to-treatment < 1 y (1 point each).
Motzer RJ, Mazumdar M, Bacik J, Berg W, Amsterdam A, Ferrara J. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol. 1999;17(8):2530-2540. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.