Second-Revision ISS (R2-ISS) for multiple myeloma
Second Revision of the ISS (R2-ISS, D’Agostino 2022): an additive 0–5 score from ISS stage, high LDH, del(17p), t(4;14), and gain(1q), grouped into four strata.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- ISS stage
- ISS III
- LDH above normal
- Yes
- del
- No
- t
- No
- gain / amp
- Yes
Result: R2-ISS additive score 3 of 5 -- stratum IV (high); median overall survival ~38 months.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- 0
- Stratum I (low); median OS not reached.
- 0.5-1
- Stratum II (low-intermediate); median OS ~109 months.
- 1.5-2.5
- Stratum III (intermediate-high); median OS ~69 months.
- 3-5
- Stratum IV (high); median OS ~38 months.
What you enter
- ISS stage
- LDH above normal
- del(17p)
- t(4;14)
- gain / amp(1q)
How this is calculated
D'Agostino M, Cairns DA, Lahuerta JJ, et al. Second revision of the International Staging System (R2-ISS) for overall survival in multiple myeloma: a European Myeloma Network (EMN) report within HARMONY. J Clin Oncol. 2022;40(29):3406-3418. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.