Revised ISS (R-ISS) for multiple myeloma
Revised ISS for multiple myeloma (Palumbo 2015): ISS plus high LDH and high-risk iFISH map to stage I–III.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- β2-microglobulin
- 6
- Albumin
- 3
- LDH above normal
- Yes
- High-risk iFISH
- No
Result: Revised ISS (R-ISS) stage III (ISS III with high LDH) -- 5-year overall survival ~40% in the IMWG cohort.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- I
- ISS I + normal LDH + no high-risk iFISH; 5-year OS ~82%.
- II
- All cases that are neither R-ISS I nor R-ISS III; 5-year OS ~62%.
- III
- ISS III + (high LDH OR high-risk iFISH); 5-year OS ~40%.
What you enter
- β2-microglobulin (mg/L)
- Albumin (g/dL)
- LDH above normal
- High-risk iFISH: del(17p), t(4;14), or t(14;16)
How this is calculated
Palumbo A, Avet-Loiseau H, Oliva S, et al. Revised International Staging System for multiple myeloma: a report from International Myeloma Working Group. J Clin Oncol. 2015;33(26):2863-2869. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.