mSMART Myeloma Risk Stratification
mSMART cytogenetic risk stratification for multiple myeloma (standard vs high risk) from FISH translocations, del(17p), gain(1q), S-phase, and R-ISS III / high LDH.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- t
- Yes
- del(17p) / p53 deletion
- Yes
Result: mSMART high risk (double hit) — 2 high-risk features.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- High-risk features
- t(4;14), t(14;16), t(14;20), del(17p)/p53, gain(1q)/del(1p), high S-phase, R-ISS III / high LDH.
- Groups
- High risk if any feature present; two = double hit, ≥ 3 = triple hit; standard risk otherwise.
What you enter
- t(4;14)
- t(14;16)
- t(14;20)
- del(17p) / p53 deletion
- gain(1q) / del(1p)
- High plasma-cell S-phase
- R-ISS III / high LDH
How this is calculated
Mikhael JR, Dingli D, Roy V, et al. Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus guidelines. Mayo Clin Proc. 2013;88(4):360-376. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.