Mayo MGUS progression-risk stratification
Mayo MGUS progression-risk (Rajkumar 2005): M-spike ≥ 1.5 g/dL, non-IgG isotype, and abnormal free-light-chain ratio give a 0–3 count and 20-year progression estimate.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Serum M-spike
- 2
- Immunoglobulin isotype
- IgA
- Free-light-chain κ/λ ratio
- 5
Result: Mayo MGUS 3 of 3 risk factors -- high risk, ~58% 20-year risk of progression.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- 0
- Low risk; ~5% 20-year risk of progression.
- 1
- Low-intermediate risk; ~21% 20-year risk.
- 2
- Intermediate risk; ~37% 20-year risk.
- 3
- High risk; ~58% 20-year risk.
What you enter
- Serum M-spike (g/dL)
- Immunoglobulin isotype
- Free-light-chain κ/λ ratio
How this is calculated
Rajkumar SV, Kyle RA, Therneau TM, et al. Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Blood. 2005;106(3):812-817. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.