IWPC pharmacogenetic warfarin dose
IWPC pharmacogenetic warfarin dose (Klein, NEJM 2009): a published linear model predicting the stable weekly maintenance dose from age, height, weight, race, enzyme-inducer and amiodarone use, and the VKORC1 / CYP2C9 genotypes.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Age
- 65 years
- Height
- 170 cm
- Weight
- 70 kg
- VKORC1 (-1639 G>A) genotype
- G/G
- CYP2C9 genotype
- *1/*1
- Race / ethnicity
- White / Caucasian
- Enzyme inducer
- No
- Amiodarone
- No
Result: IWPC predicted maintenance dose 41.1 mg/week
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Age
- Height
- Weight
- VKORC1 (-1639 G>A) genotype
- CYP2C9 genotype
- Race / ethnicity
- Enzyme inducer (carbamazepine, phenytoin, rifampin)
- Amiodarone
How this is calculated
International Warfarin Pharmacogenetics Consortium; Klein TE, Altman RB, Eriksson N, et al. Estimation of the warfarin dose with clinical and pharmacogenetic data. N Engl J Med. 2009;360(8):753-764. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.