Out-of-Range INR on Warfarin (CHEST 2012 Recommendations)
What the CHEST 2012 guideline suggests for an out-of-range INR on warfarin.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- INR
- 3.4
- Target range, lower end
- 2
- Target range, upper end
- 3
- Bleeding
- No evidence of bleeding
- INRs previously stable in range
- Yes
Result: continuing the current dose and testing the INR within 1 to 2 weeks (recommendation 3.2, Grade 2C).
The tool opens with these values already filled in. Replace them with your own.
What you enter
- INR
- Target range, lower end
- Target range, upper end
- Bleeding
- INRs previously stable in range (needed unless major bleeding)
How this is calculated
Citation
Holbrook A, Schulman S, Witt DM, et al. Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians guidelines. Chest 2012;141(2 Suppl):e152S-e184S, recommendations 3.1, 3.2, 9.1, 9.3. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.