Hepatic VOD / SOS definitions (Seattle, Baltimore, EBMT 2016)
Reports which of three published definitions of hepatic veno-occlusive disease a case meets.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Days since transplant
- 12
- Hepatomegaly or right upper quadrant pain of liver origin
- Yes
- Weight gain from baseline
- Weight gain above 2% but not above 5% of baseline
Result: Modified Seattle is met and the other two are not
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Modified Seattle
- Within 20 days, two of three: bilirubin above 2 mg/dL, hepatomegaly or right upper quadrant pain of liver origin, weight gain above 2% of baseline.
- Baltimore
- Within 21 days, a bilirubin at or above 2 mg/dL plus two of three: painful hepatomegaly, ascites, weight gain above 5%.
- EBMT 2016 classical
- Within 21 days, the Baltimore items.
- EBMT 2016 late-onset
- Beyond day 21: the classical picture, or histological proof, or two or more classical items with hemodynamic or ultrasound evidence.
- Where they part
- Baltimore and the 2016 criteria count nothing until the bilirubin is raised; modified Seattle counts it as one of three, so a normal bilirubin can meet one and neither of the others.
- Day 21
- No longer an exit. The late-onset category was added because disease beyond the classical window is real.
What you enter
- Days since transplant (every definition is written around this count)
- Bilirubin at or above 2 mg/dL
- Hepatomegaly or right upper quadrant pain of liver origin (the modified Seattle wording)
- Painful hepatomegaly (the Baltimore and EBMT wording; it satisfies the broader item above as well)
- Ascites
- Weight gain from baseline
- Hemodynamic or ultrasound evidence of veno-occlusive disease (a late-onset route beyond day 21)
- Histologically proven (a late-onset route beyond day 21)
How this is calculated
Mohty M, Malard F, Abecasis M, et al. Revised diagnosis and severity criteria for sinusoidal obstruction syndrome / veno-occlusive disease in adult patients. Bone Marrow Transplant. 2016;51(7):906-912, with the modified Seattle (McDonald 1993) and Baltimore (Jones 1987) criteria. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.