Chemotherapy Dose Modification for Hepatic or Renal Impairment (FDA Labels)
The FDA label's dose modification for liver or kidney function, for one chemotherapy drug at a time.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Drug
- Doxorubicin (total bilirubin)
- Total bilirubin
- 2 mg/dL
Result: Doxorubicin: Total bilirubin 1.2 to 3 mg/dL: reduce the dose by 50%.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Drug
- Total bilirubin
- Direct bilirubin (vincristine)
- Bilirubin as a multiple of the upper limit of normal (3-hour paclitaxel, docetaxel)
- AST or ALT as a multiple of the upper limit of normal
- Alkaline phosphatase as a multiple of the upper limit of normal (docetaxel)
- Creatinine clearance
- Serum creatinine (epirubicin, daunorubicin)
The other 2 fields
- Lowest platelet count after the prior course (carboplatin)
- Lowest neutrophil count after the prior course (carboplatin)
How this is calculated
Citation
FDA labels on DailyMed, dose modification for hepatic or renal impairment: doxorubicin, epirubicin, daunorubicin, idarubicin, vincristine, paclitaxel (Table 17), docetaxel, bleomycin, capecitabine, pemetrexed, dexrazoxane, and carboplatin (dose adjustment table). Read the sources: Doxorubicin ↗, ADRIAMYCIN ↗, ELLENCE ↗, Daunorubicin ↗, IDAMYCIN PFS ↗, Vincristine ↗, Paclitaxel ↗, Docetaxel ↗, Bleomycin ↗, XELODA ↗, ALIMTA ↗, Dexrazoxane ↗, Carboplatin ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.