Vancomycin First Dose and Starting Regimen
A starting vancomycin regimen worked three ways, for the reader to compare.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Population
- Adult
- Actual body weight
- 70 kg
- Adults: creatinine clearance
- 100 mL/min
- Loading dose
- 25 mg/kg
- Adults: target AUC24
- 500 mg·h/L
Result: Load 1,750 mg over at least 175 minutes. Daily maintenance estimates: Matzke × AUC 500 gives 2,177 mg, Rodvold 1,986 mg, label table 1,545 mg.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Population
- Actual body weight
- Adults: creatinine clearance
- Loading dose (adults; optional in children)
- Adults: target AUC24 (guideline 400 to 600)
- Children: age
- Children: daily dose
- Neonates: first week of life or later
How this is calculated
Citation
Rybak MJ, et al. Am J Health-Syst Pharm 2020;77:835-864 (ASHP/IDSA/PIDS/SIDP vancomycin guideline). Matzke GR, et al. Antimicrob Agents Chemother 1984;25:433-437. Rodvold KA, et al. Antimicrob Agents Chemother 1988;32:848-852. FDA label on DailyMed: renal dosing table. Read the sources: Rybak 2020 guideline ↗, Matzke 1984 ↗, Rodvold 1988 ↗, Vancomycin label ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.