Vancomycin AUC24/MIC (first-order, two-level)
AUC-guided vancomycin (ASHP/IDSA 2020, target AUC24/MIC 400-600) by the first-order two-level Sawchuk-Zaske method: k, half-life, extrapolated Cmax/Cmin, AUC24, and AUC24/MIC.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Peak level
- 30 mg/L
- Peak draw time after infusion end
- 1 h
- Trough level
- 10 mg/L
- Trough draw time after infusion end
- 10 h
- Infusion duration
- 1 h
- Dosing interval
- 12 h
- MIC
- 1 mg/L
Result: AUC24 ~453 mg*h/L, AUC24/MIC ~453 (within the 400-600 target).
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Peak level
- Peak draw time after infusion end
- Trough level
- Trough draw time after infusion end
- Infusion duration
- Dosing interval
- MIC
How this is calculated
Rybak MJ, et al. ASHP/IDSA/PIDS/SIDP consensus. Am J Health-Syst Pharm. 2020;77(11):835-864 (AUC-guided vancomycin, target AUC24/MIC 400-600). First-order two-level (Sawchuk-Zaske) method, not Bayesian. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.