Ursodeoxycholic acid response criteria (PBC)
Reports which definitions of biochemical response to ursodeoxycholic acid a patient meets.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Months on ursodeoxycholic acid
- 12
- Alkaline phosphatase now
- 240 U/L
- Alkaline phosphatase upper limit of normal
- 120 U/L
- Alkaline phosphatase before treatment
- 500 U/L
- AST
- 60 U/L
- AST upper limit of normal
- 40 U/L
- Total bilirubin
- 0.8 mg/dL
Result: a response by Barcelona and Paris I, not by Paris II
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Barcelona, 12 months
- Alkaline phosphatase falls more than 40% from baseline, or normalizes.
- Paris I, 12 months
- Alkaline phosphatase at or below 3 times the upper limit of normal, AST at or below 2 times, bilirubin at or below 1 mg/dL.
- Paris II, 12 months
- The same three tightened to 1.5 times, 1.5 times and 1 mg/dL, drawn on early-stage disease.
- Toronto, 24 months
- Alkaline phosphatase at or below 1.67 times the upper limit of normal.
- They disagree
- Each set was drawn on a different cohort against a different endpoint, so one blood draw can be a response by one set and not by another.
- What it is for
- Non-response identifies who is considered for second-line therapy. It is not a treatment decision and not a reason to stop ursodeoxycholic acid.
What you enter
- Months on ursodeoxycholic acid (the time point is part of each criterion)
- Alkaline phosphatase now
- Alkaline phosphatase upper limit of normal
- Alkaline phosphatase before treatment (Barcelona only)
- AST (the Paris sets only)
- AST upper limit of normal
- Total bilirubin (the Paris sets only)
How this is calculated
Corpechot C, Abenavoli L, Rabahi N, et al. Hepatology. 2008;48(3):871-877 (Paris I); Corpechot C, et al. J Hepatol. 2011;55(6):1361-1367 (Paris II); Pares A, et al. Gastroenterology. 2006;130(3):715-720 (Barcelona); Kumagi T, et al. Am J Gastroenterol. 2010;105(10):2186-2194 (Toronto). Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.