GLOBE Score (PBC Transplant-Free Survival)
GLOBE score for PBC transplant-free survival on ursodeoxycholic acid (Lammers 2015): age plus 1-year bilirubin, alkaline phosphatase, albumin, and platelets; > 0.30 marks a non-responder profile.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Age
- 65 years
- Bilirubin
- 1.8
- Alkaline phosphatase
- 2.5
- Albumin
- 0.95
- Platelet count
- 120 × 10⁹/L
Result: GLOBE 2.5 — above 0.30: non-responder profile, worse transplant-free survival.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Threshold
- > 0.30 marks a non-responder with worse transplant-free survival than a matched population.
What you enter
- Age
- Bilirubin (× ULN)
- Alkaline phosphatase (× ULN)
- Albumin (× LLN)
- Platelet count
How this is calculated
- Inputs
- Age plus 1-year bilirubin (× ULN), ALP (× ULN), albumin (× LLN), platelets (× 10⁹/L); albumin and platelet terms are negative.
Lammers WJ, Hirschfield GM, Corpechot C, et al. Development and validation of a scoring system to predict outcomes of patients with primary biliary cirrhosis receiving ursodeoxycholic acid therapy. Gastroenterology. 2015;149(7):1804-1812.e4. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.