UK-PBC Risk Score
UK-PBC risk score (Carbone 2016): from 12-month alkaline phosphatase, transaminase, and bilirubin plus baseline albumin and platelets, the 5-, 10-, and 15-year risk of end-stage liver disease in PBC.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Alkaline phosphatase
- 2.0
- Transaminase ALT or AST
- 1.5
- Bilirubin
- 1.0
- Baseline albumin
- 1.1
- Baseline platelets
- 1.5
Result: UK-PBC risk of end-stage liver disease — 4.7% at 5 yr, 14.9% at 10 yr, 26% at 15 yr.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Output
- Risk of transplant / liver-related death at 5, 10, 15 years via 1 − S₀^exp(LP). Complements the GLOBE score.
What you enter
- Alkaline phosphatase (× ULN, 12 mo)
- Transaminase ALT or AST (× ULN, 12 mo)
- Bilirubin (× ULN, 12 mo)
- Baseline albumin (× LLN)
- Baseline platelets (× LLN)
How this is calculated
- Inputs
- ALP, transaminase, bilirubin (× ULN at 12 mo) plus baseline albumin and platelets (× LLN).
Carbone M, Sharp SJ, Flack S, et al. The UK-PBC risk scores: derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cirrhosis. Hepatology. 2016;63(3):930-950. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.