Time Above MIC for a Dosing Regimen
Percent of the dosing interval that free drug stays above the MIC at steady state, in a one-compartment model.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Dose
- 2000 mg
- Infusion time
- 0.5 hours
- Dosing interval
- 8 hours
- Volume of distribution
- 20 L
- Half-life
- 1 hours
- Unbound fraction, from 0 to 1
- 1
- MIC
- 32 mg/L
Result: Free drug is above the MIC for 21.74% of the interval (1.739 of 8 hours); free peak 84.84 and trough 0.4687 mg/L.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Dose
- Infusion time (0 for a bolus)
- Dosing interval
- Volume of distribution
- Half-life (or enter k)
- Elimination rate constant, per hour
- Unbound fraction, from 0 to 1
- MIC
How this is calculated
Citation
Algebra on the linear one-compartment infusion model: the share of a dosing interval that the free concentration is above the MIC at steady state. No empirical constant and no target; volume, half-life and unbound fraction are reader input.
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.