Predicted Peak, Trough and Level (One Compartment)
Steady-state peak, trough and accumulation factor for an intermittent regimen in a linear one-compartment model.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Dose
- 1000 mg
- Infusion time
- 1 hours
- Dosing interval
- 12 hours
- Volume of distribution
- 50 L
- Half-life
- 12 hours
Result: Steady-state peak 38.87 mg/L and trough 20.59 mg/L; accumulation factor 2; half-life 12 hours.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Dose
- Infusion time (0 for a bolus)
- Dosing interval
- Volume of distribution
- Half-life (enter one of half-life, k or clearance)
- Elimination rate constant, per hour
- Clearance
- Dose number (optional, with the time below)
The other 3 fields
- Hours after that dose started (optional)
- A level (optional, with a target)
- Target to fall to (optional)
How this is calculated
Citation
Algebra on the linear one-compartment model with intermittent infusion: accumulation factor, steady-state peak and trough, superposition, and time to steady state. No empirical constant; every parameter is reader input.
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.