AUC From Measured Levels (Trapezoidal Rule)
Area under the concentration-time curve from measured levels by the trapezoidal rule, linear or linear-up log-down.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Samples, one per line
- 0, 10 1, 10 2, 5
- Method: linear, or linear-up-log-down
- Linear trapezoids
- Extrapolate to infinity
- No
Result: AUC 17.5 (concentration × hours) from 0 to 2 hours.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Samples, one per line: time in hours, then the concentration
- Method: linear, or linear-up-log-down
- Extrapolate to infinity (yes or no)
- Last samples to fit the terminal slope through (when extrapolating)
- Dose, for clearance (optional)
How this is calculated
Citation
Arithmetic: the trapezoidal rule on measured levels, linear or linear-up log-down, with the area past the last sample taken as that level over the terminal rate constant. No empirical constant.
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.