Carboplatin Dose (Calvert formula + FDA GFR cap)
Calvert carboplatin dose (Calvert, J Clin Oncol 1989): dose (mg) = target AUC × (GFR + 25); the GFR is capped at 125 mL/min per the FDA recommendation when the cap is on.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Target AUC
- 5 mg·min/mL
- GFR
- 140 mL/min
- Cap GFR at 125 mL/min
- Cap estimated GFR at 125 mL/min (FDA, recommended)
Result: Carboplatin dose 750 mg; estimated GFR 140 capped at 125 mL/min.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- GFR cap
- When GFR is estimated from serum creatinine, capping it at 125 mL/min prevents overdosing with IDMS-standardized assays (FDA).
- Safety
- AUC-based chemotherapy dose: confirm against your institutional protocol and an independent dose check.
What you enter
- Target AUC
- GFR (or Cockcroft-Gault CrCl)
- Cap GFR at 125 mL/min (FDA recommendation)
How this is calculated
- Formula
- Dose (mg) = target AUC × (GFR + 25). Target AUC is typically 4–6 mg/mL·min.
Calvert AH, Newell DR, Gumbrell LA, et al. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol. 1989;7(11):1748-1756. FDA recommends capping estimated GFR at 125 mL/min for carboplatin dosing (2010). Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.