PSA doubling time
PSA doubling time (Pound 1999): the time for PSA to double given two measurements (months); under ~12 months reflects more aggressive kinetics.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Earlier PSA
- 4 ng/mL
- Later PSA
- 8 ng/mL
- Interval
- 6 months
Result: PSA doubling time 6 months: under ~12 months, more aggressive kinetics.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Reading
- under ~12 months signals more aggressive disease; under ~3 months, very aggressive.
What you enter
- Earlier PSA
- Later PSA
- Interval
How this is calculated
- Formula
- PSADT = ln(2) x T / (ln(later PSA) - ln(earlier PSA)), T in months; requires a rising PSA.
Pound CR, Partin AW, Eisenberger MA, et al. Natural history of progression after PSA elevation following radical prostatectomy. JAMA. 1999;281(17):1591-1597. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.