Lymphocyte Doubling Time (CLL)
Lymphocyte doubling time: from two absolute lymphocyte counts and the interval, the projected time to double the lymphocyte count; ≤ 12 months marks a worse CLL prognosis.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Earlier absolute lymphocyte count
- 20 ×10⁹/L
- Later absolute lymphocyte count
- 40 ×10⁹/L
- Interval between counts
- 6 months
Result: Lymphocyte doubling time 6 months — worse prognosis (<= 12 months).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- <= 12 months
- Worse CLL prognosis.
- > 12 months
- More favorable. LDT = interval x ln(2) / ln(ALC2/ALC1). A prognostic estimate, not a treatment order.
What you enter
- Earlier absolute lymphocyte count
- Later absolute lymphocyte count
- Interval between counts
How this is calculated
Molica S, Alberti A. Prognostic value of the lymphocyte doubling time in chronic lymphocytic leukemia. Cancer. 1987;60(11):2712-2716. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.