CLL International Prognostic Index (CLL-IPI)
CLL-IPI (International CLL-IPI working group 2016): a 0–10 weighted score from TP53, IGHV status, β2-microglobulin, stage, and age, stratified low / intermediate / high / very high.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- TP53 del(17p) or mutation
- Yes
- IGHV unmutated
- Yes
- β2-microglobulin > 3.5 mg/L
- No
- Rai I–IV / Binet B–C
- Yes
- Age > 65 years
- No
Result: CLL-IPI 7 of 10 -- Very high risk; 5-year overall survival ~23%. Counted: TP53 del(17p)/mutation (4), IGHV unmutated (2), advanced stage (1).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- 0-1
- Low; 5-year OS ~93%.
- 2-3
- Intermediate; 5-year OS ~79%.
- 4-6
- High; 5-year OS ~63%.
- 7-10
- Very high; 5-year OS ~23%.
What you enter
- TP53 del(17p) or mutation
- IGHV unmutated
- β2-microglobulin > 3.5 mg/L
- Rai I–IV / Binet B–C
- Age > 65 years
How this is calculated
International CLL-IPI Working Group. An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI): a meta-analysis of individual patient data. Lancet Oncol. 2016;17(6):779-790. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.