CNS International Prognostic Index (CNS-IPI)
CNS International Prognostic Index (Schmitz 2016): age > 60, elevated LDH, ECOG > 1, Ann Arbor III/IV, > 1 extranodal site, and kidney/adrenal involvement sum to 0–6, banding the 2-year risk of CNS relapse in DLBCL.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Age > 60 years
- Yes
- LDH > normal
- Yes
- ECOG performance status > 1
- Yes
- Ann Arbor stage III/IV
- Yes
Result: CNS-IPI 4 — high risk (2-year CNS relapse ~10.2%).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Bands
- 2-year CNS relapse: low 0–1 (~0.6%), intermediate 2–3 (~3.4%), high 4–6 (~10.2%).
What you enter
- Age > 60 years
- LDH > normal
- ECOG performance status > 1
- Ann Arbor stage III/IV
- > 1 extranodal site
- Kidney and/or adrenal involvement
How this is calculated
- Factors
- Age > 60, LDH > normal, ECOG > 1, stage III/IV, > 1 extranodal site, kidney/adrenal involvement (1 point each).
Schmitz N, Zeynalova S, Nickelsen M, et al. CNS International Prognostic Index: a risk model for CNS relapse in patients with diffuse large B-cell lymphoma treated with R-CHOP. J Clin Oncol. 2016;34(26):3150-3156. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.