Spironolactone and Eplerenone by Potassium (FDA Label)
The step the FDA label gives for spironolactone or eplerenone.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Drug and question
- Eplerenone: dose adjustment in heart failure after MI
- Serum potassium
- 5.7 mEq/L
- Eplerenone adjustment
- 50 mg once daily
Result: The Inspra label's Table 1 steps 50 mg once daily down to 25 mg once daily.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Drug and question
- Serum potassium
- Spironolactone: eGFR
- Eplerenone adjustment: current dose
- Eplerenone start: creatinine clearance
- Eplerenone start: strong CYP3A inhibitor
- Eplerenone for hypertension: sex
- Eplerenone for hypertension: serum creatinine
The other 2 fields
- Hypertension: type 2 diabetes with microalbuminuria
- Hypertension: potassium supplement or sparing diuretic
How this is calculated
Citation
FDA labels on DailyMed: Aldactone (spironolactone) section 2.2, heart failure starting dose by potassium and eGFR; Inspra (eplerenone) section 2.1, Table 1, dose adjustment by serum potassium, and section 4, contraindications. Read the sources: Aldactone label ↗, Inspra label ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.