Metformin, SGLT2 and DPP-4 Rules by eGFR (FDA Label)
The kidney-function rule the FDA label gives for a diabetes drug.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Drug and use
- Sitagliptin (Januvia)
- Dialysis
- Not on dialysis
- eGFR
- 40 mL/min/1.73 m²
Result: The Januvia label gives 50 mg once daily.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Drug and use
- Dialysis: none, hd or pd
- eGFR (creatinine clearance for alogliptin)
How this is calculated
Citation
FDA labels on DailyMed, renal dosing sections: metformin tablets (2.3, 2.4), Jardiance (2.1, 8.6), Farxiga (2.2, 2.3), Invokana (Table 1), Januvia, saxagliptin tablets and Nesina (by creatinine clearance). Read the sources: Metformin ↗, Jardiance ↗, Farxiga ↗, Invokana ↗, Januvia ↗, Saxagliptin ↗, Nesina ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.