Isotonicity by E-Value (NaCl Equivalent)
Tonicity agent to add by the sodium chloride equivalent method, or the isotonic volume by White-Vincent.
Open the tool → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- What to work out
- Isotonic volume of water (White-Vincent)
- Solutes, one per line
- 0.5, 0.13 1.2, 0.46 6.5, 1 1, 0.67
- Final volume
- 1000 mL
Result: Dissolve the solutes in water to make 865.222 mL; that solution is isotonic by this method.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- What to work out: the tonicity agent to add (agent), or the isotonic volume of water (white-vincent)
- Solutes, one per line: weight in grams, then its sodium chloride equivalent (E-value)
- Final volume (required for the agent; optional for White-Vincent)
- Agent mode: E-value of the tonicity agent (1 for sodium chloride itself)
How this is calculated
Citation
Umar AK, Wathoni N, Hasanah AN, Kurniawansyah IS, Abdassah M. Kahar Method: A Novel Calculation Method of Tonicity Adjustment. J Pharm Bioallied Sci. 2019;11(Suppl 4):S635-S649, for the 0.9% sodium chloride basis and the White-Vincent constant. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.