Isotonicity by Freezing-Point Depression
Adjusting agent to add to a compounded solution by the freezing-point (cryoscopic) method, to a depression of 0.52 °C.
Open the tool → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Solutes, one per line
- 1, 0.6
Result: Already at or past 0.52 °C (0.6 °C): no adjusting agent is added.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Solutes, one per line: strength in % w/v, then the freezing-point depression of its 1% solution in °C
- Freezing-point depression of a 1% solution of the adjusting agent, from a reference
- Final volume
How this is calculated
Citation
Umar AK, Wathoni N, Hasanah AN, Kurniawansyah IS, Abdassah M. Kahar Method: A Novel Calculation Method of Tonicity Adjustment. J Pharm Bioallied Sci. 2019;11(Suppl 4):S635-S649, for the isotonic freezing-point depression of 0.52 °C. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.