Glucarpidase Dose and Leucovorin Spacing (Voraxaze Label)
Glucarpidase dose, vials and leucovorin spacing, as the VORAXAZE label states them.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Weight
- 70 kg
- Plasma methotrexate
- 12 µmol/L
- Delayed methotrexate clearance from impaired renal function
- Yes
- Planned glucarpidase time
- 2026-10-12T12:00
- Last leucovorin dose
- 2026-10-12T09:00
- Next leucovorin dose
- 2026-10-12T15:00
Result: Glucarpidase 3,500 Units (50 Units/kg), from 4 × 1,000-Unit vials.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Weight
- Plasma methotrexate
- Delayed methotrexate clearance from impaired renal function
- Planned glucarpidase time (YYYY-MM-DDTHH:MM, optional)
- Last leucovorin dose (YYYY-MM-DDTHH:MM, optional)
- Next leucovorin dose (YYYY-MM-DDTHH:MM, optional)
How this is calculated
Citation
FDA label on DailyMed: VORAXAZE (glucarpidase), sections 1, 2.1 (50 Units/kg), 2.2 (leucovorin at least 2 hours before or after; 48-hour and 3-day rules), 2.3 and 3 (1,000-Unit vial) and 5.2 (assay interference). Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.