IV Busulfan AUC and Dose Adjustment (Label Method)
IV busulfan AUC from timed levels and the adjusted dose, by the method on the FDA label.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Samples followed dose 1 (dose-1) or a later dose
- After dose 1
- Dose given
- 11 mg
- Concentration unit
- µM (micromolar)
- Samples, one per line
- 2, 3.6 4, 2.2 6, 1.35
- Target AUC
- 1125 µM·min
Result: AUC 1,109 µM·min, within 900 to 1350; adjusted dose 11.16 mg for a target of 1,125 µM·min.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Samples followed dose 1 (dose-1) or a later dose (later)
- Dose given
- Concentration unit: micromolar (uM) or ng/mL (ng-mL)
- Samples, one per line: hours from infusion start, then level
- Target AUC (the label gives 1125)
How this is calculated
Citation
FDA label on DailyMed, Busulfan Injection, section 8.4, Dose Adjustment Based on Therapeutic Drug Monitoring: adjusted dose = actual dose × target AUC ÷ actual AUC, target 1125 µM·min, the sampling schedule and the linear trapezoidal AUC. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.