CYP2D6 Activity Score with Duplications (CPIC)
The CYP2D6 activity score and phenotype for two alleles, copy numbers and tandems included.
Open the tool → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- First CYP2D6 allele as reported
- *1
- Second CYP2D6 allele as reported
- *41
- Duplication reported without naming the allele
- No
Result: CYP2D6 *1/*41: activity score 1.25, Normal Metabolizer.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- First CYP2D6 allele as reported (for example *1 or *1x2)
- Second CYP2D6 allele as reported
- Duplication reported without naming the allele: no or unknown
How this is calculated
Citation
CPIC (Clinical Pharmacogenetics Implementation Consortium) database, read through its API (CC0 1.0): CYP2D6 allele activity values, including copy-number and tandem rows, and the score-to-phenotype rules. Cut points as in Caudle et al., Clin Transl Sci 2020. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.