CYP2D6 Score Adjusted for an Inhibitor (CPIC Opioid Guideline)
A CYP2D6 activity score adjusted for an inhibitor by the CPIC opioid guideline's rule: strong sets it to 0, moderate halves it.
Open the tool → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- CYP2D6 activity score from the genotype
- 2
- Strength of the CYP2D6 inhibitor taken
- Moderate inhibitor
Result: Adjusted CYP2D6 activity score 1: Intermediate Metabolizer (genotype alone: 2, Normal Metabolizer).
The tool opens with these values already filled in. Replace them with your own.
What you enter
- CYP2D6 activity score from the genotype
- Strength of the CYP2D6 inhibitor taken: none, weak, moderate or strong
How this is calculated
Citation
Crews KR et al., CPIC Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy, Clin Pharmacol Ther 2021;110(4):888-896: a strong inhibitor sets the score to 0; a moderate one halves it. Bands from Caudle et al., Clin Transl Sci 2020. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.