DPYD Activity Score to Fluoropyrimidine Recommendation (CPIC)
CPIC's fluorouracil or capecitabine recommendation for a DPYD activity score.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Drug
- Fluorouracil
- DPYD variants as the report lists them, one per line
- c.1905+1G>A (*2A) Reference
Result: DPYD activity score 1.0 (Intermediate Metabolizer), fluorouracil: CPIC (Strong): "Reduce starting dose by 50% followed by titration of dose based on toxicity or therapeutic drug monitoring (if available). Patients with the c.2846A>T/c.2846A>T genotype may require >50% reduction in starting dose."
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Drug
- DPYD variants as the report lists them, one per line ("Reference" for a copy with none found)
- Or the DPYD activity score the report prints (0 to 2)
How this is calculated
Citation
CPIC DPYD and Fluoropyrimidines guideline, read through the CPIC database (CC0 1.0): DPYD variant activity values, the two-lowest-variant score rule and the recommendation rows. XELODA label (H2-Pharma), section 2.1. Read the sources: CPIC ↗, XELODA label ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.