Antibiotic Renal Dose Adjustment
Look up renal dose adjustments for commonly prescribed antibiotics.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Antibiotic and usual dose
- Cefepime: usual dose 1 g every 12 hours
- Dialysis
- Not on dialysis
- Creatinine clearance
- 45 mL/min
Result: The cefepime (Apotex) label gives 1 g every 24 hours.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Antibiotic and usual dose
- Dialysis: none, hd or pd
- Creatinine clearance (not used on dialysis)
What this is
Sophie Well covers the agents whose FDA labels include explicit CrCl- or eGFR-based dose-reduction tables - vancomycin, piperacillin-tazobactam, cefepime, meropenem, levofloxacin, ciprofloxacin, trimethoprim-sulfamethoxazole, gabapentin (frequently bundled with antibiotic regimens), and the rest of the common renal-adjusted list. Enter a patient's CrCl or eGFR and the agent, and the tool returns the dose, the interval, and the threshold the label crossed to get there.
When to use it
Use this when a patient with reduced kidney function is starting empiric or targeted antibiotics, when reviewing whether a standing order should be tapered after a creatinine bump, or when the pharmacy is verifying an order against the package insert. The dataset is a subset of FDA labels via DailyMed - it is not comprehensive across every dialysis modality or every off-label scenario - so the table is a starting point and pharmacy review remains the final check for any non-trivial renal regimen.
How this is calculated
Citation
FDA labels on DailyMed: the renal dosing table in Dosage and Administration of 22 antibiotic and antifungal labels (Macrobid: Contraindications). Each result names its label and version. Labels differ by manufacturer; check your stewardship guidance. Read the sources: Cefepime label ↗, Piperacillin-tazobactam label ↗, Vancomycin label ↗, Ciprofloxacin injection label ↗, Cipro tablets label ↗, Meropenem label ↗, Levofloxacin label ↗, Bactrim label ↗, Macrobid label ↗, Cubicin RF label ↗, Invanz label ↗, Cefazolin label ↗, Unasyn label ↗, Tazicef label ↗, Primaxin label ↗, Azactam label ↗, Teflaro label ↗, Amoxicillin label ↗, Amoxicillin-clavulanate label ↗, Cephalexin label ↗, Coly-Mycin M label ↗, Diflucan label ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.
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