Weiss System (Adrenocortical Carcinoma)
Weiss system for adrenocortical carcinoma: nine histopathologic criteria, each 1 point.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- High nuclear grade
- Yes
- Mitotic rate > 5 per 50 HPF
- Yes
- Necrosis
- Yes
Result: Weiss 3 of 9 — >= 3: adrenocortical carcinoma (malignant).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Threshold
- ≥ 3 indicates adrenocortical carcinoma (malignant); 0-2 a benign adenoma. This is the 1989 modified cutoff (the 1984 original used ≥ 4).
What you enter
- High nuclear grade (Fuhrman III-IV)
- Mitotic rate > 5 per 50 HPF
- Atypical mitotic figures
- Clear (lipid-rich) cells <= 25% of the tumor
- Diffuse architecture (> 33% of the tumor)
- Necrosis
- Venous invasion
- Sinusoidal invasion
- Capsular invasion
How this is calculated
- Criteria
- 9 items, 1 point each: high nuclear grade, mitoses > 5/50 HPF, atypical mitoses, clear cells ≤ 25%, diffuse architecture > 33%, necrosis, and venous, sinusoidal, and capsular invasion.
Weiss LM, Medeiros LJ, Vickery AL Jr. Pathologic features of prognostic significance in adrenocortical carcinoma. Am J Surg Pathol. 1989;13(3):202-206. (Original: Weiss LM. Am J Surg Pathol. 1984;8(3):163-169.) Read the sources: Weiss 1989 ↗, Weiss 1984 ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.