VACS Index 1.0 (HIV mortality)
VACS Index (Justice 2013): a continuous HIV mortality risk from age, CD4, HIV-1 RNA, hemoglobin, FIB-4 components (AST/ALT/platelets), eGFR, and hepatitis C.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Age
- 55
- CD4 count
- 250
- HIV-1 RNA
- 1000
- Hemoglobin
- 11
- AST
- 40
- ALT
- 30
- Platelets
- 150
- eGFR
- 70
- Hepatitis C co-infection
- No
Result: VACS Index 53 of 164 (FIB-4 2.68). Higher values indicate greater 5-year all-cause mortality risk along a continuous curve (published anchors: score 0 ~1.8%, score 164 ~> 85.8%); there is no per-band mortality lookup. Contributions: age 55y +12, CD4 250 +6, HIV-1 RNA +7, Hb 11 +22, FIB-4 2.68 +6.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Lower
- Lower total indicates lower 5-year all-cause mortality (anchor: score 0 ~1.8%).
- Higher
- Higher total indicates greater mortality risk along a continuous curve (anchor: score 164 ~> 85.8%).
What you enter
- Age (years)
- CD4 count (cells/µL)
- HIV-1 RNA (copies/mL)
- Hemoglobin (g/dL)
- AST (U/L)
- ALT (U/L)
- Platelets (×10⁹/L)
- eGFR (mL/min/1.73 m²)
- Hepatitis C co-infection
How this is calculated
Tate JP, Justice AC, Hughes MD, et al. An internationally generalizable risk index for mortality after one year of antiretroviral therapy. AIDS. 2013;27(4):563-572 (VACS Index 1.0). FIB-4 = (age x AST) / (platelets x sqrt(ALT)); total 0-164. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.