Non-Occupational HIV PEP Decision (CDC 2025)
Decides whether CDC's 2025 guideline recommends nonoccupational HIV PEP, and gives the regimen and follow-up.
Open the tool → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Hours since the exposure
- 12
- How the exposure happened
- Sexual (anal, vaginal, or oral), including sexual assault
- Exposure presents a substantial risk
- Yes
- Source's HIV status
- Has HIV, not durably suppressed or viral load unknown
- PrEP
- Not taking PrEP
Result: Exposure 12 hours ago to a source not durably suppressed: nPEP recommended, started now, for 28 days.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Hours since the exposure
- How the exposure happened
- Exposure presents a substantial risk
- Source's HIV status
- PrEP
How this is calculated
Tanner MR, O'Shea JG, Byrd KM, et al. Antiretroviral Postexposure Prophylaxis After Sexual, Injection Drug Use, or Other Nonoccupational Exposure to HIV -- CDC Recommendations, United States, 2025. MMWR Recomm Rep 2025;74(RR-1). Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.