FIB-4 Index for Liver Fibrosis
FIB-4 hepatic fibrosis index (Sterling 2006) = age*AST/(platelets*sqrt(ALT)).
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Age
- 55 years
- AST
- 60 U/L
- ALT
- 40 U/L
- Platelets
- 150 x10^9/L
Result: FIB-4 3.48 - rules in advanced fibrosis (PPV 65% per Sterling 2006).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- <1.45
- Rules out advanced fibrosis (NPV 90% per Sterling 2006).
- 1.45-3.25
- Indeterminate; consider further evaluation per Sterling 2006.
- >3.25
- Rules in advanced fibrosis (PPV 65% per Sterling 2006).
What you enter
- Age
- AST
- ALT
- Platelets
How this is calculated
Sterling RK, Lissen E, Clumeck N, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology. 2006;43(6):1317-1325. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.