Two-Compartment Parameters From a Biexponential Fit
Two-compartment micro-constants, volumes, clearance and half-lives from an IV bolus and a fitted biexponential curve.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- IV bolus dose
- 150
- A, fast-phase intercept
- 10
- Alpha, fast-phase rate
- 1
- B, slow-phase intercept
- 5
- Beta, slow-phase rate
- 0.1
Result: CL 2.5, Vc 10, Vss 21.25, terminal half-life 6.931.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- IV bolus dose (mg)
- A, fast-phase intercept (mg/L)
- Alpha, fast-phase rate (per h)
- B, slow-phase intercept (mg/L)
- Beta, slow-phase rate (per h)
How this is calculated
Citation
Stated arithmetic: the identities of the two-compartment model after an IV bolus, relating the biexponential constants A, alpha, B and beta to k21, k10, k12, Vc, CL, Vss and Vbeta.
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.