ROMA (Risk of Ovarian Malignancy Algorithm)
ROMA — Risk of Ovarian Malignancy Algorithm: a logistic model combining HE4, CA-125, and menopausal status; high-risk cut-points about 13.1% premenopausal and 27.7% postmenopausal.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- HE4
- 150 pmol/L
- CA-125
- 100 U/mL
- Postmenopausal
- Yes
Result: ROMA 62.1% (postmenopausal; high-risk cut-point 27.7%): elevated risk of epithelial ovarian cancer.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Premenopausal
- PI = -12.0 + 2.38 x ln(HE4) + 0.0626 x ln(CA125); high-risk cut-point about 13.1%.
- Postmenopausal
- PI = -8.09 + 1.04 x ln(HE4) + 0.732 x ln(CA125); high-risk cut-point about 27.7%.
- Probability
- ROMA% = 100 x exp(PI)/(1+exp(PI)). The cut-point is assay-platform dependent -- read it against your laboratory threshold.
What you enter
- HE4
- CA-125
- Postmenopausal
How this is calculated
Moore RG, McMeekin DS, Brown AK, et al. A novel multiple marker bioassay utilizing HE4 and CA125 to predict epithelial ovarian cancer in patients with a pelvic mass. Gynecol Oncol. 2009;112(1):40-46. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.