Poor-Metabolizer Dose Ceilings and Fractions in FDA Labels
The dose ceiling or fraction an FDA label states for a poor metabolizer, set beside the dose entered.
Open the tool → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Drug
- Tetrabenazine (Xenazine)
- Metabolizer status on the report
- Poor metabolizer
- Planned daily dose
- 62.5 mg
- Single dose
- 25 mg
Result: Over the label's ceiling for this status: 62.5 mg a day against 50 mg.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Drug
- Metabolizer status on the report
- Planned daily dose (ceiling rows)
- Single dose (tetrabenazine; iloperidone twice daily)
- Usual dose (aripiprazole, brexpiprazole, celecoxib)
- Adult or child (pimozide, pitolisant)
- Weight of a child (pimozide, pitolisant)
- Use (aripiprazole, iloperidone, celecoxib)
The other 2 fields
- CYP3A4 inhibitor (aripiprazole, brexpiprazole)
- Days since the last dose increase (pimozide)
How this is calculated
Citation
FDA labels on DailyMed, section 2 (poor-metabolizer dosage rows): Xenazine, Austedo, Ingrezza, pimozide tablets (Par), Abilify, Rexulti, Trintellix, Fanapt, Wakix, Celexa and Celebrex (also section 8.8). Read the sources: Xenazine label ↗, Austedo label ↗, Ingrezza label ↗, Pimozide label ↗, Abilify label ↗, Rexulti label ↗, Trintellix label ↗, Fanapt label ↗, Wakix label ↗, Celexa label ↗, Celebrex label ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.