MIPSS70 (Primary Myelofibrosis, Transplant-Age)
MIPSS70 for transplant-age primary myelofibrosis (Guglielmelli 2018).
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Hemoglobin < 10 g/dL
- Yes
- Leukocytes > 25 ×10⁹/L
- Yes
- Circulating blasts ≥ 2%
- Yes
- Bone-marrow fibrosis grade ≥ 2
- Yes
Result: MIPSS70 5 — high-risk (≥ 5).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Groups
- Low 0–1, intermediate 2–4, high ≥ 5. A prognostic estimate, not a transplant order.
What you enter
- Hemoglobin < 10 g/dL (+1)
- Leukocytes > 25 ×10⁹/L (+2)
- Platelets < 100 ×10⁹/L (+2)
- Circulating blasts ≥ 2% (+1)
- Bone-marrow fibrosis grade ≥ 2 (+1)
- Constitutional symptoms (+1)
- Absence of CALR type-1/like mutation (+1)
- High-molecular-risk (HMR) mutations
How this is calculated
- Weights
- Anemia, blasts, fibrosis, constitutional symptoms, absence of CALR type-1/like, HMR category each +1; leukocytosis and thrombocytopenia +2; ≥2 HMR mutations a further +2 (total 0–12).
Guglielmelli P, Lasho TL, Rotunno G, et al. MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis. J Clin Oncol. 2018;36(4):310-318. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.