MYSEC-PM (Secondary Myelofibrosis Survival)
MYSEC-PM for post-PV/ET secondary myelofibrosis survival (Passamonti 2017): age plus anemia, circulating blasts, CALR-unmutated status, thrombocytopenia, and constitutional symptoms give a weighted survival score.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Age
- 65 years
- Hemoglobin < 11 g/dL
- Yes
- Circulating blasts ≥ 3%
- Yes
Result: MYSEC-PM 13.75 — intermediate-1 risk (≥ 11 to < 14).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Groups
- Low < 11, intermediate-1 ≥ 11 to < 14, intermediate-2 ≥ 14 to < 16, high ≥ 16. For secondary (post-PV / post-ET) myelofibrosis.
What you enter
- Age
- Hemoglobin < 11 g/dL (+2)
- Circulating blasts ≥ 3% (+2)
- CALR-unmutated (+2)
- Platelets < 150 ×10⁹/L (+1)
- Constitutional symptoms (+1)
How this is calculated
- Formula
- 0.15·age + hemoglobin <11 g/dL (+2) + circulating blasts ≥3% (+2) + CALR-unmutated (+2) + platelets <150 ×10⁹/L (+1) + constitutional symptoms (+1).
Passamonti F, Giorgino T, Mora B, et al. A clinical-molecular prognostic model to predict survival in patients with post polycythemia vera and post essential thrombocythemia myelofibrosis. Leukemia. 2017;31(12):2726-2731. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.