GIPSS (Genetically Inspired Prognostic Score, PMF)
GIPSS genetically inspired prognostic score for primary myelofibrosis (Tefferi 2018): karyotype category plus CALR-type-1 absence, ASXL1, SRSF2, and U2AF1-Q157 mutations sum to a purely genetic risk score.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Karyotype
- Very-high-risk (+2)
- ASXL1 mutation
- Yes
Result: GIPSS 3 — high risk (≥ 3).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Groups
- Low 0, intermediate-1 1, intermediate-2 2, high ≥ 3. The mutation-and-karyotype-only companion to MIPSS70.
What you enter
- Karyotype
- Absence of CALR type-1/like mutation (+1)
- ASXL1 mutation (+1)
- SRSF2 mutation (+1)
- U2AF1 Q157 mutation (+1)
How this is calculated
- Weights
- VHR karyotype +2 or unfavorable +1; absence of CALR type-1/like +1; ASXL1 +1; SRSF2 +1; U2AF1 Q157 +1 (total 0–6).
Tefferi A, Guglielmelli P, Nicolosi M, et al. GIPSS: genetically inspired prognostic scoring system for primary myelofibrosis. Leukemia. 2018;32(7):1631-1642. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.