Milan Criteria (HCC transplant eligibility)
Milan criteria (Mazzaferro 1996) for HCC liver-transplant eligibility: a single tumor <= 5 cm or up to three tumors each <= 3 cm, with no macrovascular invasion and no extrahepatic spread.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Number of HCC nodules
- 1
- Largest tumor size
- 4.5 cm
Result: Within Milan criteria: a single HCC <= 5 cm, no macrovascular invasion, no extrahepatic spread.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Within
- A single tumor <= 5 cm OR <= 3 nodules each <= 3 cm, AND no macrovascular invasion AND no extrahepatic spread.
- Caveat
- Reports the criterion only -- not a listing decision (MELD allocation, downstaging, UCSF/extended criteria, and center policy all apply).
What you enter
- Number of HCC nodules
- Largest tumor size
- Macrovascular invasion
- Extrahepatic spread
How this is calculated
Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334(11):693-699. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.