Kobayashi Score (IVIG Resistance, Kawasaki)
Kobayashi score (Kobayashi 2006): predicts IVIG resistance in Kawasaki disease from pre-treatment values.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Serum sodium
- 131 mmol/L
- Day of illness at start of treatment
- 4 days
- AST
- 150 IU/L
- Neutrophil percentage
- 84 %
- CRP
- 11 mg/dL
- Age
- 8 months
- Platelet count
- 350 x10^3/uL
Result: Kobayashi 10 of 11 — high risk of IVIG resistance (>= 4).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- < 4
- Lower risk of IVIG resistance.
- >= 4
- High risk of IVIG resistance (derivation ~76-86% sensitivity / ~68-70% specificity; lower in Western and infant cohorts). A resistance-risk band, not an IVIG or steroid order.
What you enter
- Serum sodium (mmol/L)
- Day of illness at start of treatment
- AST (IU/L)
- Neutrophil percentage (%)
- CRP (mg/dL)
- Age (months)
- Platelet count (x10^3/uL)
How this is calculated
- Points
- sodium <=133 (2), treatment by day 4 (2), AST >=100 (2), neutrophils >=80% (2), CRP >=10 (1), age <=12 months (1), platelets <=300 x10^3/uL (1) = 0-11.
Kobayashi T, Inoue Y, Takeuchi K, et al. Prediction of intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease. Circulation. 2006;113(22):2606-2612. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.