Hepamet Fibrosis Score (NAFLD Advanced Fibrosis)
Hepamet fibrosis score (Ampuero 2020): a non-invasive advanced-fibrosis score for NAFLD from age, sex, AST, albumin, platelets, diabetes, and HOMA-IR; < 0.12 rules out and ≥ 0.47 rules in advanced fibrosis.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Age
- 68 years
- Sex
- Male
- AST
- 90 IU/L
- Albumin
- 3.5 g/dL
- Platelets
- 120 ×10⁹/L
- Diabetes mellitus
- Yes
Result: Hepamet 0.948 — advanced fibrosis ruled IN (≥ 0.47).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Cut-points
- < 0.12 rules OUT advanced fibrosis, ≥ 0.47 rules it IN, 0.12–0.47 indeterminate. A non-invasive score built to shrink the FIB-4 / NFS gray zone; a stratifier, not a biopsy order.
What you enter
- Age
- Sex
- AST
- Albumin
- Platelets
- Diabetes mellitus (if set, HOMA-IR is not needed)
- HOMA-IR (non-diabetic only)
How this is calculated
- Inputs
- Age, sex, AST, albumin, HOMA-IR (non-diabetic only), diabetes, and platelets, entered into the published categorical logistic HFS = 1 / (1 + e^E). The diabetes term replaces the HOMA terms.
Ampuero J, Pais R, Aller R, et al. Development and Validation of Hepamet Fibrosis Scoring System–Based on Simple, Available, and Objective Metrics for Advanced Fibrosis in Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2020;18(1):216-225.e5. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.