Agile 3+ (FibroScan Advanced Fibrosis Probability)
Agile 3+ (Sanyal 2023): a FibroScan-anchored probability of advanced (≥ F3) fibrosis in NAFLD from liver stiffness, AST, ALT, platelets, diabetes, sex, and age; < 0.451 rules out and ≥ 0.679 rules in.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Liver stiffness (LSM) by VCTE / FibroScan
- 12 kPa
- AST
- 50 IU/L
- ALT
- 40 IU/L
- Platelets
- 180 ×10⁹/L
- Age
- 60 years
- Sex
- Male
- Diabetes mellitus
- Yes
Result: Agile 3+ 0.868 — advanced fibrosis ruled IN (≥ 0.679).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Cut-points
- < 0.451 rules OUT advanced fibrosis, ≥ 0.679 rules it IN, 0.451–0.679 indeterminate. Outperforms LSM alone; takes the LSM the operator reads from the device. A stratifier, not a biopsy order.
What you enter
- Liver stiffness (LSM) by VCTE / FibroScan
- AST
- ALT
- Platelets
- Age
- Sex
- Diabetes mellitus
How this is calculated
- Inputs
- LSM (kPa) by VCTE / FibroScan, AST, ALT, platelets, age, sex, and diabetes, entered into the published logistic Agile 3+ = 1 / (1 + e^−logit) for advanced (≥ F3) fibrosis.
Sanyal AJ, Foucquier J, Younossi ZM, et al. Enhanced diagnosis of advanced fibrosis and cirrhosis in individuals with NAFLD using FibroScan-based Agile scores. J Hepatol. 2023;78(2):247-259. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.