Drug Clearance by CRRT (Flow and Sieving Coefficient)
Drug clearance by continuous renal replacement therapy from the effluent flows and a sieving or saturation coefficient.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Mode: hemofiltration, hemodialysis or hemodiafiltration
- Hemofiltration (CVVH)
- Flow unit
- mL/hour
- Ultrafiltrate flow
- 2000
- Sieving coefficient
- 0.8
- Patient's other clearance
- 10 mL/min
Result: CRRT clears 26.67 mL/min (1.6 L/hour), 72.73% of a total of 36.67 mL/min.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Mode: hemofiltration, hemodialysis or hemodiafiltration
- Flow unit: mL/hour (mL-h), mL/min (mL-min) or L/hour (L-h)
- Ultrafiltrate flow (filtration modes)
- Sieving coefficient (filtration modes)
- Dialysate flow (dialysis modes)
- Saturation coefficient (dialysis modes)
- Plasma flow (with fluid before the filter)
- Pre-filter flow
- Patient's other clearance (optional)
How this is calculated
Citation
Li L, et al. Front Pharmacol. 2020;11:786 (convective clearance = sieving coefficient × ultrafiltrate flow; diffusive = saturation coefficient × dialysate flow); Corona A, et al. Antibiotics. 2022;11:1811 (hemofiltration with fluid given before the filter). Read the sources: Li 2020 ↗, Corona 2022 ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.