CLIF-C ACLF (acute-on-chronic liver failure)
CLIF-C ACLF (Jalan 2014): the six-organ CLIF-OF sub-score (6–18) plus age and white-cell count → a 0–100 acute-on-chronic-liver-failure mortality score.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Liver — bilirubin sub-score
- 2
- Kidney — creatinine sub-score
- 3
- Brain — West Haven HE sub-score
- 2
- Coagulation — INR sub-score
- 1
- Circulation — MAP / vasopressor sub-score
- 2
- Respiration — PaO2/FiO2 sub-score
- 1
- Age
- 55
- White-cell count
- 12
Result: CLIF-C ACLF 54 (CLIF-OF organ-failure sub-score 11/18): a higher score indicates higher short-term mortality in acute-on-chronic liver failure.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- CLIF-OF
- six organ systems (liver, kidney, brain, coagulation, circulation, respiratory) each 1-3, total 6-18; circulation scores 3 for vasopressor use.
What you enter
- Liver — bilirubin sub-score
- Kidney — creatinine sub-score
- Brain — West Haven HE sub-score
- Coagulation — INR sub-score
- Circulation — MAP / vasopressor sub-score
- Respiration — PaO2/FiO2 sub-score
- Age (years)
- White-cell count (×10⁹/L)
How this is calculated
- Formula
- CLIF-C ACLF = 10 x [0.33 x CLIF-OF + 0.04 x age + 0.63 x ln(WBC) - 2], 0-100; higher means higher short-term mortality.
Jalan R, Saliba F, Pavesi M, et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol. 2014;61(5):1038-1047. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.